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J Am Acad Dermatol (2014) 71:125768.e4

In addition to these conventional sites of mitochondrial ROS generation, it has been recently reported that the branched-chain 2-oxoacid dehydrogenase (BCKDH) complex in mitochondria can produce superoxide and H 2 O 2 at higher rates than complex I from mitochondria (Quinlan et al., 2014)

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The objective is to conduct a metabolomic analysis, employing multidimensional and one-dimensional approaches to identify metabolite differences between the two groups and screen potential biomarkers for early LN detection and treatment monitoring